diff --git a/frontend/src/core/threads/hooks.test.ts b/frontend/src/core/threads/hooks.test.ts
index 646de7a7..ddd7d8f4 100644
--- a/frontend/src/core/threads/hooks.test.ts
+++ b/frontend/src/core/threads/hooks.test.ts
@@ -1,7 +1,7 @@
 import assert from "node:assert/strict";
 import test from "node:test";
 
-const { buildFilesForSubmit } = await import(
+const { buildFilesForSubmit, materializeArtifactReferences } = await import(
   new URL("./submit-files.ts", import.meta.url).href
 );
 
@@ -48,3 +48,62 @@ void test("buildFilesForSubmit drops stale references without blocking submit",
   assert.equal(result.staleCount, 1);
   assert.equal(result.files.length, 0);
 });
+
+void test("materializeArtifactReferences converts artifact references to upload paths", async () => {
+  const references = await materializeArtifactReferences(
+    [
+      {
+        filename: "artifact.md",
+        path: "/mnt/user-data/outputs/artifact.md",
+        ref_kind: "mention",
+        ref_source: "artifact",
+      },
+      {
+        filename: "uploaded.md",
+        path: "/mnt/user-data/uploads/uploaded.md",
+        ref_kind: "mention",
+        ref_source: "upload",
+      },
+    ],
+    {
+      fetchArtifactBlob: async () =>
+        new Blob(["artifact"], { type: "text/plain" }),
+      uploadArtifact: async () => ({
+        filename: "artifact.md",
+        size: 8,
+        path: "/host/path/artifact.md",
+        virtual_path: "/mnt/user-data/uploads/artifact.md",
+        artifact_url: "/api/threads/t1/artifacts/mnt/user-data/uploads/artifact.md",
+      }),
+    },
+  );
+
+  assert.equal(references.length, 2);
+  assert.equal(references[0]?.ref_source, "upload");
+  assert.equal(references[0]?.path, "/mnt/user-data/uploads/artifact.md");
+  assert.equal(references[1]?.path, "/mnt/user-data/uploads/uploaded.md");
+});
+
+void test("materializeArtifactReferences marks artifact as stale on upload failure", async () => {
+  const references = await materializeArtifactReferences(
+    [
+      {
+        filename: "broken.md",
+        path: "/mnt/user-data/outputs/broken.md",
+        ref_kind: "mention",
+        ref_source: "artifact",
+      },
+    ],
+    {
+      fetchArtifactBlob: async () => new Blob(["artifact"]),
+      uploadArtifact: async () => null,
+    },
+  );
+
+  assert.equal(references.length, 1);
+  assert.equal(references[0]?.stale, true);
+
+  const result = buildFilesForSubmit([], references);
+  assert.equal(result.staleCount, 1);
+  assert.equal(result.files.length, 0);
+});
diff --git a/frontend/src/core/threads/hooks.ts b/frontend/src/core/threads/hooks.ts
index 6c036da4..b068cd52 100644
--- a/frontend/src/core/threads/hooks.ts
+++ b/frontend/src/core/threads/hooks.ts
@@ -10,6 +10,7 @@ import type {
 } from "@/components/ai-elements/prompt-input";
 
 import { getAPIClient } from "../api";
+import { urlOfArtifact } from "../artifacts/utils";
 import { getBackendBaseURL } from "../config";
 import { useI18n } from "../i18n/hooks";
 import type { FileInMessage } from "../messages/utils";
@@ -19,7 +20,7 @@ import type { UploadedFileInfo } from "../uploads";
 import { uploadFiles } from "../uploads";
 import type { UploadTarget } from "../uploads/api";
 
-import { buildFilesForSubmit } from "./submit-files";
+import { buildFilesForSubmit, materializeArtifactReferences } from "./submit-files";
 import type {
   AgentThread,
   AgentThreadContext,
@@ -59,6 +60,34 @@ const STREAM_CANCEL_PATTERNS = [
   /\babort(?:ed|error)?\b/i,
 ];
 
+async function convertArtifactReferencesToUploads(
+  threadId: string,
+  references: PromptInputMessage["references"],
+) {
+  return materializeArtifactReferences(references, {
+    fetchArtifactBlob: async (reference) => {
+      const filepath = reference.path;
+      if (!filepath) {
+        throw new Error("Missing artifact path");
+      }
+      const response = await fetch(
+        urlOfArtifact({
+          filepath,
+          threadId,
+        }),
+      );
+      if (!response.ok) {
+        throw new Error("Failed to read artifact");
+      }
+      return response.blob();
+    },
+    uploadArtifact: async (file) => {
+      const response = await uploadFiles(threadId, [file]);
+      return response.files[0];
+    },
+  });
+}
+
 function readMessageCandidate(value: unknown): string | null {
   if (typeof value === "string" && value.trim()) {
     return value.trim();
@@ -553,9 +582,15 @@ export function useThreadStream({
         }
 
         // Build files metadata for submission (single envelope for uploads + references)
+        const normalizedReferences = resolvedThreadId
+          ? await convertArtifactReferencesToUploads(
+              resolvedThreadId,
+              message.references,
+            )
+          : (message.references ?? []);
         const { files: filesForSubmit, staleCount } = buildFilesForSubmit(
           uploadedFileInfo,
-          message.references,
+          normalizedReferences,
         );
         if (staleCount > 0) {
           toast.error("部分引用已失效，已自动移除");
@@ -714,9 +749,12 @@ export function useSubmitThread({
         }
       }
 
+      const normalizedReferences = threadId
+        ? await convertArtifactReferencesToUploads(threadId, message.references)
+        : (message.references ?? []);
       const { files: filesForSubmit, staleCount } = buildFilesForSubmit(
         [],
-        message.references,
+        normalizedReferences,
       );
       if (staleCount > 0) {
         toast.error("部分引用已失效，已自动移除");
diff --git a/frontend/src/core/threads/submit-files.ts b/frontend/src/core/threads/submit-files.ts
index a82d3091..02d1ab91 100644
--- a/frontend/src/core/threads/submit-files.ts
+++ b/frontend/src/core/threads/submit-files.ts
@@ -10,6 +10,51 @@ export type MentionReference = {
   stale?: boolean;
 };
 
+type ArtifactMaterializer = (
+  file: File,
+) => Promise<UploadedFileInfo | null | undefined>;
+type ArtifactBlobFetcher = (reference: MentionReference) => Promise<Blob>;
+
+export async function materializeArtifactReferences(
+  references: MentionReference[] = [],
+  options: {
+    fetchArtifactBlob: ArtifactBlobFetcher;
+    uploadArtifact: ArtifactMaterializer;
+  },
+): Promise<MentionReference[]> {
+  const result: MentionReference[] = [];
+  for (const reference of references) {
+    if (
+      reference.ref_source !== "artifact" ||
+      !reference.path ||
+      reference.stale
+    ) {
+      result.push(reference);
+      continue;
+    }
+
+    try {
+      const blob = await options.fetchArtifactBlob(reference);
+      const file = new File([blob], reference.filename, {
+        type: blob.type || "application/octet-stream",
+      });
+      const uploaded = await options.uploadArtifact(file);
+      if (!uploaded?.virtual_path) {
+        result.push({ ...reference, stale: true });
+        continue;
+      }
+      result.push({
+        ...reference,
+        ref_source: "upload",
+        path: uploaded.virtual_path,
+      });
+    } catch {
+      result.push({ ...reference, stale: true });
+    }
+  }
+  return result;
+}
+
 export function buildFilesForSubmit(
   uploadedFileInfo: UploadedFileInfo[],
   references: MentionReference[] = [],
diff --git a/frontend/tests/e2e/input-and-compose.spec.ts b/frontend/tests/e2e/input-and-compose.spec.ts
index 6de5b93c..03862d0e 100644
--- a/frontend/tests/e2e/input-and-compose.spec.ts
+++ b/frontend/tests/e2e/input-and-compose.spec.ts
@@ -128,8 +128,11 @@ test.describe("聊天工作台 / 输入区与发送", () => {
     skipIfMissingThread(testInfo, THREAD_FOR_WELCOME, "FRONTEND_E2E_THREAD_ID");
     await openChat(page, reuseThreadChatEntry(THREAD_FOR_WELCOME!));
 
+    const expander = page.locator("div.absolute.inset-0.z-1.cursor-text");
+    if ((await expander.count()) > 0) {
+      await expander.first().click();
+    }
     const textarea = page.locator("textarea[name='message']");
-    await textarea.click();
     await textarea.fill("请基于这个文件回答 @");
 
     const panel = page.getByTestId("mention-candidate-panel").first();
@@ -138,7 +141,7 @@ test.describe("聊天工作台 / 输入区与发送", () => {
     const itemCount = await items.count();
     testInfo.skip(itemCount === 0, "当前线程没有可引用文件候选。");
 
-    await items.first().click();
+    await textarea.press("Enter");
     await expect(textarea).toBeFocused();
     await expect(textarea).toHaveValue(/请基于这个文件回答/);
     await expect(page.getByTestId("reference-inline-preview")).toBeVisible();
@@ -163,8 +166,11 @@ test.describe("聊天工作台 / 输入区与发送", () => {
     skipIfMissingThread(testInfo, THREAD_FOR_WELCOME, "FRONTEND_E2E_THREAD_ID");
     await openChat(page, reuseThreadChatEntry(THREAD_FOR_WELCOME!));
 
+    const expander = page.locator("div.absolute.inset-0.z-1.cursor-text");
+    if ((await expander.count()) > 0) {
+      await expander.first().click();
+    }
     const textarea = page.locator("textarea[name='message']");
-    await textarea.click();
     await textarea.fill("请参考这些文件 ");
 
     await textarea.type("@");
@@ -178,14 +184,20 @@ test.describe("聊天工作台 / 输入区与发送", () => {
       await textarea.type("@");
       const currentPanel = page.getByTestId("mention-candidate-panel").first();
       await expect(currentPanel).toBeVisible();
-      await currentPanel.locator("button").nth(i).click();
+      for (let step = 0; step < i; step += 1) {
+        await textarea.press("ArrowDown");
+      }
+      await textarea.press("Enter");
     }
 
     await expect(page.getByLabel("移除引用")).toHaveCount(6);
 
     await textarea.type("@");
     await expect(panel).toBeVisible();
-    await panel.locator("button").nth(6).click();
+    for (let step = 0; step < 6; step += 1) {
+      await textarea.press("ArrowDown");
+    }
+    await textarea.press("Enter");
 
     await expect(page.getByLabel("移除引用")).toHaveCount(6);
     await expect(page.getByText("单条消息最多引用 6 个文件")).toBeVisible();